ABSTRACT
Obesity is becoming an epidemic health problem. Elevated cytokines and chemokines are prominent features in obesity, which play a main role in the development of other chronic diseases. The aim of this study was to determine the serum levels of monocyte chemoattractant protein-1 [MCP-1], interlukin-6 [IL-6], and serum paraoxonase-1 [PON1] in childhood obesity. The present study included 40 obese school-aged children [5-15 years] and 40 healthy children as controls. The patients were presented to the outpatient clinic in National Institute of Nutrition. MCP-1, IL-6, PON1, total cholesterol, and triglycerides were measured in all participants. The mean serum levels of MCP-1, IL-6, and total cholesterol were significantly higher in obese participants than in controls [P < 0.0001], whereas the PON1 was significantly lower in obese participants than in controls [P < 0.0001]. MCP-1, IL-6, and serum cholesterol levels showed significant positive correlation with BMI [P < 0.05], whereas PON1 showed a significant negative correlation with BMI [P < 0.05]. Multiple regression analysis showed a strong association between PON1 activity and BMI [P < 0.0001]. Childhood obesity is associated with increased serum MCP-1 and IL-6 and decreased PON1 and hypercholesterolemia suggesting an increase in adulthood disease risk. Measuring serum MCP-1, IL-6, PON1 activity in obese children may be a good predictor for future chronic disease development and complications
ABSTRACT
Diabetes mellitus and osteoporosis are chronic disease with great socioeconomic consequences, mainly due to the late complications and consequences disabilities. Type I diabetes mellitus [DM 1] has been related to a reduced bone mineral density [BMD] in childhood. In order to evaluate alternation in the one metabolism in type I diabetes we measured a urine osteocalsic marker for bone resorption; deoxypyridinoline [DPD] as well as, the circulating osteoblastic markers; serum osteocalcin and osteoprotegerin [OPG]. Further more, we evaluated their relation to the disease duration and severity. The influenced of sex and age on bone health were also assessed. Cross-sectional case-control study was conducted on forty children with DMI and twenty control subjects matched for age and sex with similar socioeconomic and cultural status. Serum levels of osteocalcin and osteoprotegerin were measured, also urinary levels of deoxypyridinoline [DPD] was measured. Children with DMI showed lower serum levels of osteoclacin and OPG and a rise in urinary level of [DPD] in comparison with control subjects. The osteoblast function significantly decreased in diabetic patients, which one best is characterized as a maturation defect. Altered bone mineral acquisition in children with DMI may limit peak bone mass acquisition and increase the risk of osteoporosis in later life. So the clinical management of diabetic osteopenia would become important for the reservation of quality of life in diabetic patients